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Chemical extractions of soil organic matter (SOM) have not been widely used to elucidate the dynamics of SOM in field settings, especially to address issues of nutrient cycling. To illustrate potential applications of chemical extractions to nutrient issues, this report reviews studies in which the extraction of SOM fractions was based on their binding to polyvalent soil cations. Radiocarbon ag...
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Understanding the mechanisms of evolution requires identification of the molecular basis of the multiple (pleiotropic) effects of specific adaptive mutations. We have characterized the pleiotropic effects on protein levels of an adaptive single–base pair substitution in the coding sequence of a signaling pathway gene in the bacterium Pseudomonas fluorescens SBW25. We find 52 proteomic changes, ...
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Metabolism-dependent inhibition (MDI) of cytochrome P450 (P450) enzymes has the potential to cause clinically relevant drug-drug interactions. In the case of several alkylamine drugs, MDI of P450 involves formation of a metabolite that binds quasi-irreversibly to the ferrous heme iron to form a metabolic intermediate (MI) complex. The specific metabolites coordinately bound to ferrous iron and ...
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in the French–American and British (FAB) classification and represents approximately 5—10% of all leukemia in adults. In about 95—98% of the cases, APL is associated with the reciprocal translocation, t(15; 17)(q22; q21) and the reciprocal fusion of the retinoic acid receptor (RAR)a gene on chromosome 17 with the promyelocytic leukemia (PML) gene on chromosome 15. The resulting PML-RARa fusion ...
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ژورنال
عنوان ژورنال: Stahlbau
سال: 2022
ISSN: ['1437-1049', '0038-9145']
DOI: https://doi.org/10.1002/stab.202270907